What role do copy number variants play in schizophrenia?

Copy number variants (CNVs) are significant structural variations in the genome that involve the duplication or deletion of segments of DNA. In the context of schizophrenia, research has indicated that CNVs contribute to the genetic risk associated with the disorder. They are not simply incidental; rather, studies show that specific CNVs are more frequently observed in individuals diagnosed with schizophrenia compared to the general population.

The presence of these variants can disrupt gene function, affect neural development, and alter the biological pathways involved in brain function. This link between CNVs and schizophrenia highlights their role in the broader genetic landscape of the disorder, suggesting that while they may not be the sole cause of schizophrenia, they are indeed an important factor in the genetic risk profile for the condition.

Understanding the contributions of CNVs helps researchers and clinicians identify potential genetic markers for susceptibility and opens avenues for targeted interventions. This context underscores the relevance and importance of CNVs in the study of schizophrenia and their functional impact on the risk of developing the disorder.