What is the best response to a patient who states that the origin of most cancer is genetic?

The assertion that the origin of most cancers is genetic is supported by the understanding that cancer develops when there are alterations in the genes of cells. These genetic changes can lead to uncontrolled cell growth and the formation of tumors. While it is true that various factors contribute to cancer risk—including environmental influences and lifestyle choices—the underlying mechanism often involves genetic mutations that affect cell function.

Genetic alterations can be inherited, as seen in familial cancer syndromes, or acquired due to environmental exposure or lifestyle factors, such as smoking or UV radiation. However, the option that emphasizes genetic changes directly aligns with the biological basis of how cancer operates at the cellular level. Therefore, stating that cancers arise in cells that have alteration in the genes accurately reflects current scientific understanding of cancer etiology. This response acknowledges the complexity of cancer development while emphasizing the crucial role that genetics plays.